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KLH in Publications

Publications of scientific research involving KLH. Abstracts or full text articles are available by link to outside sites. If you know of a KLH-related publication that is not yet on KLH Site™, let us know.

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Entries in TDAR (127)


Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti-CD28 Domain Antibody Antagonist in Healthy Subjects

Rong Shi PhD, Marek Honczarenko MD, PhD, Sean Zhang MD, Catherine Fleener MS, Johanna Mora PhD, Sun Ku Lee PhD, Reena Wang MD, Xiaoni Liu PhD, Diane E. Shevell PhD, Zheng Yang PhD, Haiqing Wang PhD, Bindu Murthy PharmD.

J Clin Pharmacol. 2017 Feb;57(2):161-172. doi: 10.1002/jcph.791. Epub 2016 Aug 23.


Keyhole limpet haemocyanin – a model antigen for human immunotoxicological studies

Ashwin Swaminathan, Robyn M Lucas, Keith Dear, and Anthony J McMichael




T-cell-dependent antibody responses in the rat: Forms and sources of keyhole limpet hemocyanin matter

Lebrec H, Hock MB, Sundsmo JS, Mytych DT, Chow H, Carlock LL, Joubert MK, Reindel J, Zhou L, Bussiere JL.

J Immunotoxicology 2013 August 20 (Epub ahead of print)



T Cell Dependent Antibody Responses in the Rat: Forms and Sources of Keyhole Limpet Hemocyanin Matter

H. Lebrec1, M. B. Hock2, J. Sundsmo3, D. Mytych2, H. Chow3, L. Carlock1, M. K. Joubert2 and J. L. Bussiere2. 1 Amgen, Seattle, WA; 2 Amgen, Thousand Oaks, CA; 3 Stellar Biotechnologies, Port Hueneme, CA.

Abstract published March 2013 online.

Poster presented March 14, 2013.

The Toxicologist
Supplement to Toxicological Sciences
An Official Journal of the Society of Toxicology
ISSN 1096-6080
Volume 132, Issue 1, Page 440
March 2013



Neoantigen and tumor antigen-specific immunity transferred from immunized donors is detectable early after allogeneic transplantation in myeloma patients

Foglietta M, Neelapu SS, Kwak LW, Jiang Y, Nattamai D, Lee ST, Fowler DH, Sportes C, Gress RE, Steinberg SM, Vence LM, Radvanyi L, Dwyer KC, Qazilbash MH, Bryant RN, Bishop MR

Bone Marrow Transplant. 2013 Feb;48(2):269-77. doi: 10.1038/bmt.2012.132. Epub 2012 Jul 9


Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study.

Tonk EC, de Groot DM, Wolterbeek AP, Penninks AH, Waalkens-Berendsen ID, Piersma AH, van Loveren H

Arch Toxicol. 2013 Feb;87(2):323-35. doi: 10.1007/s00204-012-0940-1. Epub 2012 Sep 25


Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats

Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T

J Immunotoxicol. 2013 Jan;10(1):40-8. doi: 10.3109/1547691X.2012.691122. Epub 2012 Sep 7


Immunodeficiency and autoimmunity in H2-O-Deficient mice


The effect of a mixture of dairy-based feed ingredients, vegetable fats, and yeast cell walls on performance and innate immunity of weaned piglets

Gerritsen R, Klaassen GJ, Schuttert G, Rouwers SM, Parmentier HK, Molist F

J Anim Sci. 2012 Dec;90 Suppl 4:269-71. doi: 10.2527/jas.51742


Ontogeny of Adaptive Antibody Response to a Model Antigen in Captive Altricial Zebra Finches

Tess L. Killpack and William H. Karasov

PLoS One. 2012; 7(10): e47294.


Immunotoxic effects of cyclophosphamide and cyclosporine in the dog.

Legrand JJ, Bouchez C, Mimouni C, N'guyen A, Bouchard J, Ameller T, Descotes J.

J Immunotoxicol. 2012 Oct 3. [Epub ahead of print]


A method for inducing antigen-specific IgG production by in vitro immunization


Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats

Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T

J Immunotoxicol. 2012 Sep 7. [Epub ahead of print]


Dietary intake of resveratrol enhances the adaptive immunity of aged rats


Multiparametric immunotoxicity screening in mice during early drug development

Aulí M, Domènech A, Andrés A, Orta M, Salvà M, Descotes J, Prats N

Toxicol Lett. 2012 Aug 31;214(2):200-208. doi: 10.1016/j.toxlet.2012.08.020. [Epub ahead of print]


A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival.

Lowe M, Badell IR, Thompson P, Martin B, Leopardi F, Strobert E, Price AA, Abdulkerim HS, Wang R, Iwakoshi NN, Adams AB, Kirk AD, Larsen CP, Reimann KA

Am J Transplant. 2012 Aug;12(8):2079-87. doi: 10.1111/j.1600-6143.2012.04054.x. Epub 2012 May 8


Development of a Delayed-Type Hypersensitivity (DTH) Model in the Cynomolgus Monkey

Bouchez C, Gervais F, Fleurance R, Palate B, Legrand JJ, Descotes J

J Toxicol Pathol. 2012 Jun;25(2):183-8.


Active Therapeutic Immunization with TNF-Kinoid in Rheumatoid Arthritis Patients with Secondary Resistance to TNFα Antagonists is safe and immunogenic.

Durez P, Miranda P , Toncheva A, Berman A, Rillo OL, Boutsen Y, Kehler T, Mociran E, Soto Saez LA, Fautrel B, Mariette X, Solakov P, Lucero E, Vlak T, Grazio S, Mastrovic K, Chiriac R, Grouard-Vogel G, Dhellin O, Ouary S, Vandepapelière P, Boissier MC

Eular 2012 (June 8-9)


A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival

M. Lowe, I. R. Badell, P. Thompson, B. Martin, F. Leopardi, E. Strobert, A. A. Price, H. S. Abdulkerim, R. Wang, N. N. Iwakoshi, A. B. Adams, A. D. Kirk, C. P. Larsen, K. A. Reimann

American Journal of Transplantation, May 8, 2012, DOI: 10.1111/j.1600-6143.2012.04054



Humoral anti-KLH responses in cancer patients treated with dendritic cell-based immunotherapy are dictated by different vaccination parameters

Aarntzen EH, de Vries IJ, Göertz JH, Beldhuis-Valkis M, Brouwers HM, van de Rakt MW, van der Molen RG, Punt CJ, Adema GJ, Tacken PJ, Joosten I, Jacobs JF.

Cancer Immunol Immunother. 2012 Apr 21. [Epub ahead of print]