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KLH in Publications

Publications of scientific research involving KLH. Abstracts or full text articles are available by link to outside sites. If you know of a KLH-related publication that is not yet on KLH Site™, let us know.

(in order by date)

Entries in Systemic Lupus Erythematosus (SLE) (7)

Wednesday
Feb012017

Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti-CD28 Domain Antibody Antagonist in Healthy Subjects

Rong Shi PhD, Marek Honczarenko MD, PhD, Sean Zhang MD, Catherine Fleener MS, Johanna Mora PhD, Sun Ku Lee PhD, Reena Wang MD, Xiaoni Liu PhD, Diane E. Shevell PhD, Zheng Yang PhD, Haiqing Wang PhD, Bindu Murthy PharmD.

J Clin Pharmacol. 2017 Feb;57(2):161-172. doi: 10.1002/jcph.791. Epub 2016 Aug 23.

Friday
Apr082016

Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus

B A Sullivan, W Tsuji, A Kivitz, J Peng, G E Arnold, M J Boedigheimer, K Chiu, C L Green, A Kaliyaperumal, C Wang, J Ferbas, and J B Chung

Lupus Sci Med. 2016; 3(1): e000146.
Published online 2016 Apr 8. doi:  10.1136/lupus-2016-000146

Relates to Clinical Trials: NCT02391259 and NCT00774943

 

Wednesday
Sep022015

IFNα kinoid induces neutralizing anti-IFNα antibodies that decrease the expression of IFN-induced and B cell activation associated transcripts : analysis of extended follow-up data from the IFN-K phase I/II study

J. Ducreux1, P. Vandepapeliere2, F. Colaone2, C. Roucairol2, T. Croughs2, F. A. Houssiau1, G. Grouard-Vogel2, B. Lauwerys1
(1Université catholique de Louvain, Brussels, Belgium, 2Neovacs, Paris, France)

Poster presented September 4, 2015

Lupus 2015
11th International Congress on Systemic Lupus Erythematosus
Vienna, Austria
Sept. 2 - 6, 2015

Friday
Oct252013

Administration Of AMG 557, A Human Anti-B7RP-1 (ICOSL) Antibody, Leads To The Selective Inhibition Of Anti-KLH IgG Responses In Subjects With SLE: Results Of A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Sequential, Rising, Multiple-Dose Study.

Sullivan,  Barbara, Tsuji,  Wayne H., Chindalore,  Vishala L., Geppert,  Thomas D., Rudinskaya,  Alla, Pardo,  Patricia, Kivitz,  Alan.

Arthritis & Rheumatism, Volume 65, October 2013 Abstract Supplement

Abstracts of the 2013 American College of Rheumatology/Association of Rheumatology Health Professionals Annual Meeting
San Diego, CA

October 25-30, 2013.

Friday
Sep132013

Anti-interferon alpha treatment in SLE.

Thursday
Aug012013

A novel assay to measure B cell responses to keyhole limpet haemocyanin vaccination in healthy volunteers and subjects with systemic lupus erythematosus

John Ferbas, Shelley S Belouski, Michelle Horner, Arunan Kaliyaperumal, Li Chen, Malcolm Boyce, C Bernie Colaço, Neil McHugh, Vanessa Quick, Richard J Nicholl, Gerald Siu, and James Chung

Br J Clin Pharmacol. 2013 Aug; 76(2): 188–202

Wednesday
Jun012011

Active immunisation of human interferon α transgenic mice with a human interferon α Kinoid induces antibodies that neutralise interferon α in sera from patients with systemic lupus erythematosus.