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KLH in Publications

Publications of scientific research involving KLH. Abstracts or full text articles are available by link to outside sites. If you know of a KLH-related publication that is not yet on KLH Site™, let us know.

(in order by date)

Entries in Assay - ELISA (55)


Monitoring of dynamic changes in Keyhole Limpet Hemocyanin (KLH)-specific B cells in KLH-vaccinated cancer patients

Florian Wimmers, Nienke de Haas, Anja Scholzen, Gerty Schreibelt, Elles Simonetti, Marc J. Eleveld, Huberdina M. L. M. Brouwers, Marjo Beldhuis-Valkis, Irma Joosten, Marien I. de Jonge, Winald R. Gerritsen, I. Jolanda M. de Vries, Dimitri A. Diavatopoulos, Joannes F. M. Jacobs.


Wimmers, F. et al. Monitoring of dynamic changes in Keyhole Limpet Hemocyanin(KLH)-specific B cells in KLH-vaccinated cancer patients. Sci. Rep. 7, 43486; doi: 10.1038/srep43486 (2017).




Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A

de Medina P, Paillasse MR, Segala G, Al Saati T, Boyes J, Delsol G, Allal C, Marsili S, Silvente-Poirot S, Poirot M.

Biochimie. 2013 Mar;95(3):482-8. doi: 10.1016/j.biochi.2012.06.001. Epub 2012 Jun 16


Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens

Pravetoni M, Le Naour M, Tucker AM, Harmon TM, Hawley TM, Portoghese PS, Pentel PR

J Med Chem. 2013 Feb 14;56(3):915-23. doi: 10.1021/jm3013745. Epub 2013 Jan 15


Toward Identifying the Effects of the Specific Components of Mindfulness-Based Stress Reduction on Biologic and Emotional Outcomes Among Older Adults

Gallegos AM, Hoerger M, Talbot NL, Krasner MS, Knight JM, Moynihan JA, Duberstein PR

J Altern Complement Med. 2013 Feb 5. [Epub ahead of print]


Prediction and identification of B-cell linear epitopes of hepatitis B e antigen

Yang J, Liu N, Zhang T, Zhao SP, Qiang L, Su BS, Kang AJ, Li ZF

Nan Fang Yi Ke Da Xue Xue Bao. 2013 Feb;33(2):253-7


Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study.

Tonk EC, de Groot DM, Wolterbeek AP, Penninks AH, Waalkens-Berendsen ID, Piersma AH, van Loveren H

Arch Toxicol. 2013 Feb;87(2):323-35. doi: 10.1007/s00204-012-0940-1. Epub 2012 Sep 25


Preparation and characterization of monoclonal antibody specific for copper-chelate complex


Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats

Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T

J Immunotoxicol. 2013 Jan;10(1):40-8. doi: 10.3109/1547691X.2012.691122. Epub 2012 Sep 7


Pharmacodynamic effects of steady-state fingolimod on antibody response in healthy volunteers: a 4-week, randomized, placebo-controlled, parallel-group, multiple-dose study.


The effect of a mixture of dairy-based feed ingredients, vegetable fats, and yeast cell walls on performance and innate immunity of weaned piglets

Gerritsen R, Klaassen GJ, Schuttert G, Rouwers SM, Parmentier HK, Molist F

J Anim Sci. 2012 Dec;90 Suppl 4:269-71. doi: 10.2527/jas.51742


Preparation, identification and application of monoclonal antibody against matrix metalloproteinases-2


Synthesis of hapten and preparation of specific polyclonal antibody with high affinity for lenalidomide, the potent drug for treatment of multiple myeloma

Darwish IA, Alzoman NZ, Abuhejail RM, El-Samani TE

Chem Cent J. 2012 Oct 26;6(1):125. [Epub ahead of print]


Ontogeny of Adaptive Antibody Response to a Model Antigen in Captive Altricial Zebra Finches

Tess L. Killpack and William H. Karasov

PLoS One. 2012; 7(10): e47294.


Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats

Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T

J Immunotoxicol. 2012 Sep 7. [Epub ahead of print]


Humoral anti-KLH responses in cancer patients treated with dendritic cell-based immunotherapy are dictated by different vaccination parameters

Aarntzen EH, de Vries IJ, Göertz JH, Beldhuis-Valkis M, Brouwers HM, van de Rakt MW, van der Molen RG, Punt CJ, Adema GJ, Tacken PJ, Joosten I, Jacobs JF.

Cancer Immunol Immunother. 2012 Apr 21. [Epub ahead of print]


Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep

Jean A Hall, Rachel L Sendek, Rachel M Chinn, D Paul Bailey, Katie N Thonstad, Yongqiang Wang, Neil E Forsberg, William R Vorachek, Bernadette V Stang, Robert J Van Saun, and Gerd Bobe.

Vet Res. 2011; 42(1): 99


Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients 

Joannes F.M. Jacobs, Cornelis J.A. Punt1, W. Joost Lesterhuis, Roger P.M. Sutmuller, H. Mary-lène H. Brouwer, Nicole M. Scharenborg, Ina S. Klasen, Luuk B. Hilbrands, Carl G. Figdor, I. Jolanda M. de Vries, Gosse J. Adema

Clin Cancer Res October 15, 2010 16; 5067


Anthrax Spore Detection by a Luminex Assay Based on Monoclonal Antibodies That Recognize Anthrose-Containing Oligosaccharides

Marco TamborriniMarcelle HolzerPeter H. SeebergerNadia SchürchGerd Pluschke

Clin Vaccine Immunol September 2010 vol. 17 no. 9 1446-1451


In vitro naïve T cell proliferation failure predicts poor post-immunization responses to neoantigen, but not recall antigens, in HIV-infection.

Rodriguez B, Valdez H, Lange CG, Asaad R, Medvik K, Sieg SF.

Clin Immunol. 2010 Sep;136(3):400-8. Epub 2010 May 15.


Immunization responses in rheumatoid arthritis patients treated with rituximab: results from a controlled clinical trial

Bingham CO 3rd, Looney RJ, Deodhar A, Halsey N, Greenwald M, Codding C, Trzaskoma B, Martin F, Agarwal S, Kelman A.

Arthritis Rheum 2010 Jan;62(1):64-74