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KLH in Publications

Publications of scientific research involving KLH. Abstracts or full text articles are available by link to outside sites. If you know of a KLH-related publication that is not yet on KLH Site™, let us know.

(in order by date)

Entries in Antibody Response IgM (71)


Keyhole limpet haemocyanin – a model antigen for human immunotoxicological studies

Ashwin Swaminathan, Robyn M Lucas, Keith Dear, and Anthony J McMichael




T-cell-dependent antibody responses in the rat: Forms and sources of keyhole limpet hemocyanin matter

Lebrec H, Hock MB, Sundsmo JS, Mytych DT, Chow H, Carlock LL, Joubert MK, Reindel J, Zhou L, Bussiere JL.

J Immunotoxicology 2013 August 20 (Epub ahead of print)



T Cell Dependent Antibody Responses in the Rat: Forms and Sources of Keyhole Limpet Hemocyanin Matter

H. Lebrec1, M. B. Hock2, J. Sundsmo3, D. Mytych2, H. Chow3, L. Carlock1, M. K. Joubert2 and J. L. Bussiere2. 1 Amgen, Seattle, WA; 2 Amgen, Thousand Oaks, CA; 3 Stellar Biotechnologies, Port Hueneme, CA.

Abstract published March 2013 online.

Poster presented March 14, 2013.

The Toxicologist
Supplement to Toxicological Sciences
An Official Journal of the Society of Toxicology
ISSN 1096-6080
Volume 132, Issue 1, Page 440
March 2013



Toward Identifying the Effects of the Specific Components of Mindfulness-Based Stress Reduction on Biologic and Emotional Outcomes Among Older Adults

Gallegos AM, Hoerger M, Talbot NL, Krasner MS, Knight JM, Moynihan JA, Duberstein PR

J Altern Complement Med. 2013 Feb 5. [Epub ahead of print]


Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats

Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T

J Immunotoxicol. 2013 Jan;10(1):40-8. doi: 10.3109/1547691X.2012.691122. Epub 2012 Sep 7


Immunodeficiency and autoimmunity in H2-O-Deficient mice


A method for inducing antigen-specific IgG production by in vitro immunization


Oral tolerance induction in humans


Immunotoxic effects of cyclophosphamide and cyclosporine in the dog.

Legrand JJ, Bouchez C, Mimouni C, N'guyen A, Bouchard J, Ameller T, Descotes J.

J Immunotoxicol. 2012 Oct 3. [Epub ahead of print]


Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors

Gonzalez-Lopez de Turiso F, Shin Y, Brown M, Cardozo M, Chen Y, Fong D, Hao X, He X, Henne K, Hu YL, Johnson MG, Kohn T, Lohman J, McBride HJ, McGee LR, Medina JC, Metz D, Miner K, Mohn D, Pattaropong V, Seganish J, Simard JL, Wannberg S, Whittington DA, Yu G, Cushing TD.

J Med Chem. 2012 Sep 13;55(17):7667-85. Epub 2012 Aug 29


A method for inducing antigen-specific IgG production by in vitro immunization


Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats

Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T

J Immunotoxicol. 2012 Sep 7. [Epub ahead of print]


Multiparametric immunotoxicity screening in mice during early drug development

Aulí M, Domènech A, Andrés A, Orta M, Salvà M, Descotes J, Prats N

Toxicol Lett. 2012 Aug 31;214(2):200-208. doi: 10.1016/j.toxlet.2012.08.020. [Epub ahead of print]


Keyhole Limpet Hemocyanin (KLH): A Unique, Unlikely Pharmaceutical Product

H. Chow, M. Sagermann and J. Sundsmo

ImVacs 2012 Abstract

ImVacs 2012 Poster

The Immunotherapeutics and Vaccine Summit
August 13-16, 2012
Cambridge, MA USA


Humoral anti-KLH responses in cancer patients treated with dendritic cell-based immunotherapy are dictated by different vaccination parameters

Aarntzen EH, de Vries IJ, Göertz JH, Beldhuis-Valkis M, Brouwers HM, van de Rakt MW, van der Molen RG, Punt CJ, Adema GJ, Tacken PJ, Joosten I, Jacobs JF.

Cancer Immunol Immunother. 2012 Apr 21. [Epub ahead of print]


Pharmacodynamic Effects of Steady-State Fingolimod on Antibody Response in Healthy Volunteers: A 4-Week, Randomized, Placebo-Controlled, Parallel-Group, Multiple-Dose Study.

Boulton C, Meiser K, David OJ, Schmouder R

J Clin Pharmacol. 2011 Dec 15. [Epub ahead of print]


Humoral Immune Response to Keyhole Limpet Haemocyanin, the Protein Carrier in Cancer Vaccines

A. Kantele, M.P. Hakkinen, J. Zivny, C.O. Elson, J. Mestecky, and J.M. Kantele.

Clin Dev Immunol. 2011;2011:614383. Epub 2011 Jun 12


An inter-laboratory retrospective analysis of immunotoxicological endpoints in non-human primates: T-cell-dependent antibody responses

Lebrec H, Cowan L, Lagrou M, Krejsa C, Neradilek MB, Polissar NL, Black L, Bussiere J.

J Immunotoxicol. 2011 Jul-Sep;8(3):238-50. Epub 2011 Jun 21


Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients 

Joannes F.M. Jacobs, Cornelis J.A. Punt1, W. Joost Lesterhuis, Roger P.M. Sutmuller, H. Mary-lène H. Brouwer, Nicole M. Scharenborg, Ina S. Klasen, Luuk B. Hilbrands, Carl G. Figdor, I. Jolanda M. de Vries, Gosse J. Adema

Clin Cancer Res October 15, 2010 16; 5067


Cardiovascular Exercise Intervention Improves the Primary Antibody Response to Keyhole Limpet Hemocyanin (KLH) in Previously Sedentary Older Adults

R.W. Grant, R.A. Mariani, V. J. Vieira, M. Fleshner, T. P. Smith, K.T. Keylock, T.W. Lowder, E. McAuley, L. Hu, K. Chapman-Novakofski, and J.A. Woods.

Brain Behav Immun. 2008 August; 22(6):923-932