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KLH in Publications

Publications of scientific research involving KLH. Abstracts or full text articles are available by link to outside sites. If you know of a KLH-related publication that is not yet on KLH Site™, let us know.

(in order by date)


Vaccines against drugs of abuse: where are we now?


Natalizumab treatment shows no clinically meaningful effects on immunization responses in patients with relapsing-remitting multiple sclerosis.

Kaufman MPardo GRossman HSweetser MTForrestal FDuda P.

J Neurol Sci. 2014 Jun 15;341(1-2):22-7. doi: 10.1016/j.jns.2014.03.035. Epub 2014 Mar 26.



Effect of Currently Approved Carriers and Adjuvants on the Pre-Clinical Efficacy of a Conjugate Vaccine against Oxycodone in Mice and Rats

Pravetoni M, Vervacke JSDistefano MDTucker AMLaudenbach MPentel PR.

PLOS One. 2014 May 5;9(5):e96547

doi: 10.1371/journal.pone.0096547. eCollection 2014.


The peritrophic membrane of the gastropod Megathura crenulata: structure, composition, and site of formation


Ecological Distribution and Radula Morphology of the Giant Keyhole Limpet (Megathura crenulata)

Adrienne Mikovari

G Martin, J Williams, D Pondella
Occidental College, Department of Biology, Los Angeles, CA

Poster presented April 3-5, 2014

NCUR 2014 
National Conference on Undergraduate Research 2014
April 3-5, 2014 


Keyhole Limpet Hemocyanin (KLH): Protecting the Sole Marine Source of an Important Pharmaceutical Product

Catherine Brisson and Brandon Lincicum.
Stellar Biotechnologies, Inc.

Poster presented March 3-4, 2014

Gordon Research Conference: Marine Natural Products
Ventura, California
March 2-7, 2014


Synthetic HIV-1 matrix protein p17-based AT20-KLH therapeutic immunization in HIV-1-infected patients receiving antiretroviral treatment: A phase I safety and immunogenicity study.

Iaria MLFiorentini SFocà EZicari SGiagulli CCaccuri FFrancisci DDi Perri GCastelli FBaldelli FCaruso A.

Vaccine 2014 Feb 19;32(9):1072-8. doi: 10.1016/j.vaccine.2013.12.051. Epub 2014 Jan 20.


Modulating Cocaine Vaccine Potency through Hapten Fluorination

Xiaoqing CaiKyoji Tsuchikama, and Kim D. Janda.

J. Am. Chem. Soc., 2013135 (8), pp 2971–2974


When is a keyhole limpet a giant?: A rapid and inexpensive assay to verify Megathura crenulata hemocyanin

Eernisse D, Smith J, McCune K, Lincicum B.
California State University, Fullerton and Stellar Biotechnologies, Inc.

Poster presented Feb 9-12, 2014

Aquaculture America 2014 (World Aquaculture Society)
Seattle, Washington USA
February 9-12, 2014


Keyhole limpet hemocyanin augmented the killing activity, cytokine production and proliferation of NK cells, and inhibited the proliferation of Meth A sarcoma cells in vitro

Md. Moklesur Rahman Sarker and Ming Zhong.

Indian J Pharmacol. 2014 Jan-Feb; 46(1): 40–45.


The future of blood-based biomarkers for Alzheimer's disease

Kim Henriksen, Sid E. O’Bryant, Harald Hampel, John Q. Trojanowski, Thomas J. Montine, Andreas Jeromin, Kaj Blennow, Anders Lönneborg, Tony Wyss-Coray, Holly Soares, Chantal Bazenet, Magnus Sjögren, William Hu, Simon Lovestone, Morten A. Karsdal, Michael W. Weiner

Alzheimers Dement. 2014 Jan;10(1):115-31. doi: 10.1016/j.jalz.2013.01.013. Epub 2013 Jul 11.



OX40 is a potent immune-stimulating target in late-stage cancer patients.

Curti BDKovacsovics-Bankowski MMorris NWalker EChisholm LFloyd KWalker JGonzalez IMeeuwsen TFox BAMoudgil TMiller WHaley D,Coffey TFisher BDelanty-Miller LRymarchyk NKelly TCrocenzi TBernstein ESanborn RUrba WJWeinberg AD.

Cancer Res. 2013 Dec 15;73(24):7189-98. doi: 10.1158/0008-5472.CAN-12-4174. Epub 2013 Oct 31.

Full Text 

Relates to Clinical Trial NCT01644968


Vaccination with Clostridium difficile PSII polysaccharide antigen adjuvanted with KLH induced broad-based enhancement of adaptive immune responses and protection in mice

Herbert Chow, Martin Sagermann, Zuchao Ma, Gayatri Vandentam, and Mario A. Monteiro.

Poster presented Oct 27-29, 2013

7th Vaccine and ISV Congress
Sitges, Spain
October 27-29, 2013.  


Administration Of AMG 557, A Human Anti-B7RP-1 (ICOSL) Antibody, Leads To The Selective Inhibition Of Anti-KLH IgG Responses In Subjects With SLE: Results Of A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Sequential, Rising, Multiple-Dose Study.

Sullivan,  Barbara, Tsuji,  Wayne H., Chindalore,  Vishala L., Geppert,  Thomas D., Rudinskaya,  Alla, Pardo,  Patricia, Kivitz,  Alan.

Arthritis & Rheumatism, Volume 65, October 2013 Abstract Supplement

Abstracts of the 2013 American College of Rheumatology/Association of Rheumatology Health Professionals Annual Meeting
San Diego, CA

October 25-30, 2013.


An anti-C. difficile PSII polysaccharide-KLH conjugate vaccine is efficacious in mice

Brittany Pequegnat, Martin Sagermann, Luis Arroyo, Herbert Chow and Mario A. Monteiro8th


Oral presentation Oct 25, 2013

International Conference on the Molecular Biology and Pathogenesis of the Clostridia (ClostPath 8)
Queensland, Australia
October 22-26, 2013.


Immunotherapy for Alzheimer’s disease: hoops and hurdles


A Monovalent Anti-Human CD28 Domain Antibody Antagonist: Preclinical Efficacy and Safety

Suzanne J. Suchard, Patricia M. Davis, Selena Kansal, Dawn K. Stetsko, Ruth Brosius, James Tamura, Lumelle Schneeweis, James Bryson, Theodora Salcedo, Haiqing Wang, Zheng Yang, Catherine A. Fleener, Olga Ignatovich, Christopher Plummer, Steven Grant, and Steven G. Nadler

The Journal of Immunology, 2013, 191: 000–000.


Anti-interferon alpha treatment in SLE.


Adjuvant Ganglioside GM2-KLH/QS-21 Vaccination Versus Observation After Resection of Primary Tumor > 1.5 mm in Patients With Stage II Melanoma: Results of the EORTC 18961 Randomized Phase III Trial

Alexander M.M. EggermontStefan SuciuPiotr RutkowskiJeremy MarsdenMario SantinamiPhilippa CorrieSteinar AamdalPaolo A. AsciertoPoulam M. PatelWim H. KruitLars BastholtLorenzo BorgognoniMaria Grazia BernengoNeville DavidsonLarissa PoldersMichel Praet and Alan Spatz

JCO September 9, 2013JCO.2012.47.9303


T-cell-dependent antibody responses in the rat: Forms and sources of keyhole limpet hemocyanin matter

Lebrec H, Hock MB, Sundsmo JS, Mytych DT, Chow H, Carlock LL, Joubert MK, Reindel J, Zhou L, Bussiere JL.

J Immunotoxicology 2013 August 20 (Epub ahead of print)